In the present study, synthesized nanostructured merwinite (Ca3MgSi2O8) bioactive coatings were successfully prepared by plasma-spray coating method. The phase composition and microstructure of the powders were examined by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. Also the properties of the prepared coating were evaluated using XRD, AFM, SEM coupled with Energy-Dispersive X-ray analaysis and micro hardness analysis. XRD analysis indicated pure merwinite coatings were obtained. A uniform structure of the merwinite coating was found across the Ti-6Al4V surface, with a thickness and surface roughness of the coating of about 16 and 0.252 + ?0.02 μm, respectively. The results indicated that merwinite coating was obtained with a uniform and dense microstructure at the interface of the Ti-6A l-4V surface. Taken together, the results obtained indicated that plasma sprayed merwinite coating may be a candidate for orthopedic implants.