Purpose: The purpose of this study was to investigate agitation in home-dwelling persons with dementia and coping behaviors of primary family care-givers to agitation. Methods: The research was designed as a descriptive study. A total of two hundred and five subjects had participated in this study. To measure agitation in persons with dementia, Cohen-Mansfield Agitation Inventory was used. To measure coping behaviors of primary family care-givers to the agitation, a questionnaire was used. Descriptive statistics, t-test, ANOVA, Scheffe? test were used to answer the research objectives. Results: 'Repetitive mannerisms' and 'repeating sentences' were the most commonly occurred agitation in home-dwelling persons with dementia. 'Leaving the situation', 'allowing certain time', and 'soothing by talking' were the most common coping behaviors occurred in primary care-givers. Conclusion: The findings of the current study would provide meaningful data to develop nursing programs to control agitation for home-dwelling persons with dementia and education programs for primary care-givers to cope with persons' agitation.