The antitoxic effect of red ginseng extract to cadmium toxicity on protein patterns and total protein content in the serum of goldfish, Carassius auratus, was investigated. Nine serum protein fractions appeared in the normal goldfish and 8 fractions except IgG appeared in the cadmium and cadmiumred ginseng groups. The amount of albumin, α₁-, β-globulin fractions were decreased and that of α₂-, γ-globulin fractions were increased in the cadmium and cadmium-red ginseng groups. The total serum protein content in the cadmium and cadmium-red ginseng groups were decreased in comparison with the control.