This experiment was carried out to investigate the effects of protein levels and DI-methionine supplementation on the plasma cholesterol levels and the growth rate of chicks fed semi-purified diets containing soybean oil meal and perilla oil meal as dietary protein sources. One hundred male chicks of 10 day old S.C.W. Leghorn were alloted into 10 lots. The treatments imposed were three different levels of protein (15, 20 and 25%) and three levels of DL-methionine supplementation (0, 0.1 and 0.2%) as 3×3 factorial design. Fish meal was added at the level of 12% to compare its effect on various items with vegetable protein source only at optimal protein level (20%). The experimental results obtained were as follows: 1) The growth rate was highly significantly (P$lt;0.01) improved as the level of protein was increased. But there was no significant difference between the levels of methionine. Also, highly significant improvement was appeared in growth rate by fish meal fed chickens. 2) Highly significant difference was observed in the amount of feed-intake by the chicks fed the diet containing different level of dietary protein. Chicks fed 15% protein consumed significantly (P$lt;0.05) less amounts of diet than those fed 20 or 25% protein level S. Dietary protein level of either 20 or 25% did not result any significant difference in the feed consumption, 3) Feed efficiency was significantly (P$lt;0.01) improved as the level of protein was increased and also by supplementing excess amount of DL-methionine. Fish meal increased not only feed consumption amount but also improved feed efficiency as 2.47 compared with 3.11 of 0.1% DL-methionine supplementation group. 4) Plasma cholesterol levels were significantly (P$lt;0.01) increased when chicks were fed diets containing 15% protein level. Chicks fed the diet of 25% protein level showed the lowest level of plasma cholesterol. In comparison with 0.1% and 0.2% of DL-methionine supplementation groups in each protein level, feeding of the excess amount of methionine significantly (P$lt;0.01) depressed cholesterol levels in chicks fed 15 and 20% protein diet. No difference was found in plasma cholesterol level in fish meal lot. 5) Although, no significant difference was observed in metabolizability of energy between chicks of 0.1 and 0.2% DL-methionine supplementation groups, the former showed higher values than those of the latter. Chicks fed 25% protein diet showed the lowest value of metabolizable energy (M.E.) (P$lt;0.01). Fish meal increased the valve of M.E. with no significance. 6) The percentages of Nitrogen retention was the lowest in groups of 25% protein level (P$lt;0.01) but showed no difference between each level of methionine supplementation or between each treatment of 20% protein diet.