18.97.14.90
18.97.14.90
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새로운 항균제로서 1 - ( phenoxymethyl ) benzotriazole 유도체의 합성과 정량적 구조활성관계 ( QSAR ) 분석
Synthesis and quantitative structure - activity relationships ( QSAR ) analysis of 1 - ( phenoxymethyl ) benzotriazole derivatives as new fungicide
성낙도(Nack Do Sung), 임치환(Chi Hwan Lim), 최우영(Woo Young Choi), 고동성(Thoug Sung Ko), 권기성(Ki Sung Kwon)
UCI I410-ECN-0102-2008-520-000744491

The structure-antifungal activity correlations between the structure of fourteen new 1-(phenoxymethyl)benzotriazoles (I) (Y=0), 1-(thiophenoxyrnethyl)benzotriazoles (II) (Y=S) and 1-(azidomethyl)benzotriazole (Ⅲ) derivatives were synthesized, and their activity, fifty percent inhibition of mycelial growth(pI_(50)), in vitro against Pyricularia oryzae, Fusarium axysporum f. sp swami, Valsa ceratosperma and Botrytis cinerea were investigated using a generalized QSAR method. The activity of (I) was superior to those of (II) and (Ⅲ). The effect of the substituents (X) on the phenoxy group (I) was rationalized by a parabolic function of electronic (σ), steric (B₁) and hydrophobic parameter(π), and hydrogen bonding (HB). Where the optimal values of substituent on the fungicidal activity againt P. oryzae and F. axcysporum f. sp. sesami are B₁=1.40A; (H) and σ=0.07∼0.15;(H), and those of substituent on the fungicidal activity against V. ceratosperma and B. dare σ=0.23∼0.28; (Cl), π=0.70; (Cl), respectively. The most effective compound ( I a) and ( I d) were examined in this study.

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