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18.97.14.91
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Candidate SCIE SCOPUS
Gene-Specific Repair of 6-4 Photoproducts in Trichothiodystrophy Cells
(Sheila Nathan) , (Annmeke van Hoffen) , (Leon H. F. Mullenders) , (Lynne V. Mayne)
BMB Reports vol. 32 iss. 6 554-560(7pages)
UCI I410-ECN-0102-2009-470-007262706

TTDIBI cells are non-hypersensitive to UV irradiation and perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and, concomitantly, are unable to restore RNA synthesis levels following UV irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of 6-4 photoproducts at the gene-level. The results indicated a defect in gene-specific repair of 6-4 photoproducts in active genes, although strand-specificity of 6-4 photoproduct removal was essentially similar to that of normal cells. These findings indicate that the near normal UV resistance of TTDIBI cells may be due to the inability of these cells to remove DNA lesions preferentially, as well as to the cells opting out of the cell cycle to repair damage before resuming replication.

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