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18.97.9.169
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SCIE SCOPUS
신규 퀴놀론 항균제 DW-116 의 in vitro 및 in vovp 항균활성
In vitro and In vivo Antibacterial Activity of DW-116 , a New Quinolone Antibiotic
이진(Jin Lee),정용호(Yong Ho Chung),윤성준(Sung June Yoon),이덕근(Dug Keun Lee),황연하(Yun Ha Hwang),한경오(Kyung Oh Han),양희복(Hee Bog Yang)
UCI I410-ECN-0102-2009-510-008085959
* This article is free of use.

The in vitro and in vivo antibacterial activity of DW-116, a newly synthesized fluoroquinolone, were compared with those of other quinolones. DW-116 exhibited more potent antibacterial activity than rufloxacin and lower activity than ofloxacin and ciprofloxacin in in vitro assay. But, DW-116 particularly showed strong activity against the family of staphylococci including methicillin-sensitive staphylococcus and its activity was more active than that of ciprofloxacin. The time-kill curve studies showed rapid bactericidal activity for DW-116. The post-antibiotic effect of DW-116 was observed between 0.66 and 5 hours. The therapeutic efficacy of DW-116 against respiratory infection with P. aeruginosa was as strong as that of ciprofloxacin and its effect against urinary tract infection with E. coli was more effective than rufloxacin. The excellent therapeutic efficacy of DW-116 against these local infections is due to its good pharmacokinetic profiles.

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