For the screening of antidiabetic effect, this study was carried out to some natural products by measurements of glucose level. MeOH and CH₂Cl₂ extracts of natural products were investigated for the effect on glucose level of N₂-STZ diabeted Rat. Among the natural products, Dioscorea Rhizoma, Trichosanthes Radix, Nelumbis Semem and Lycii Fructus were shown a remarkable antidiabetic effect.