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SCIE SCOPUS
랫드에서 생약복합제 SKI306X 의 급성독성에 관한 연구
Acute Toxicity of SKI306X , an Antiinflammatory Herbal Extract , in Rats
안재석(Jae Suk Ahn),김훈택(Hun Taek Kim),조용백(Yong Baik Cho),김환수(Hwan Su Kim),박광식(Kwang Sik Park),박병욱(Pyeong Uk Park)
UCI I410-ECN-0102-2009-510-008086825
This article is 4 pages or less.
* This article is free of use.

SKI306X is a herbal extract prepared from three herbs Clematis mandshurica, Trichosanthes kirilowii and Prunella vulgaris. It showed strong antiinflammalory actions on carrageenan-induced edema, acetic acid-induced pain, adjuvant-induced arthritis, and oxygen radical-generated reactions. In this study, the acute toxicity of SKI306X was evaluated in rats by a single oral administration. Thirty male and thirty female rats were divided into 6 groups according to the dose levels, respectively. After oral administration of SKI306X with several doses (5.0 g/㎏, 3.3 g/㎏, 2.2 g/㎏, 1.5 g/㎏, 1.0 g/㎏), mortality, clinical signs, body weight, and gross findings in organs were examined. No toxic effect was shown in terms of mortality, clinical signs, body weight changes and gross findings. It is suggested the LD_(50) of SKI306X would be more than 5.0 g/㎏ in rats.

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