Arbitration agreement is a cornerstone of the arbitration, which demonstrates the common intention of the parties. The parties’ autonomy may give rise to good or bad consequences. The terms and conditions of the arbitration agreement shall not be obscured by drafting incongruities, which are capital sins that must be avoided under any circumstances. If the arbitration agreement is properly drafted, efficient and smooth arbitration can be ensured, but if drafted carelessly, it can invite sundry matters, including practical and legal issues. However, if it is badly drafted, it can be the host of pathology that may impede its enforcement. To that end, this article critically analyses various types of pathological clauses, including asymmetric, blank, defective, and uncertain or unclear, by surveying comparative courts’ jurisprudence to unearth and highlight the canons of judicial interpretation towards the enforceability and validity of pathological arbitration clauses. In order to prevent arbitration clauses from pathology, this article scrutinises the model arbitration clauses provided by various international arbitral institutions. In addition, this article figures out the major and supplementary provisions likely to be part of arbitration agreements, as lawyers or drafters can utilise these provisions in a comprehensive commercial setting of arbitration agreements.