Purpose: The study investigates the degree of maternal self- esteem, postpartal depression, and family function in mothers of normal and of low birth-weight infants. Method: A retrospective cohort design was applied to compare the variables of interest between a group of 73 mothers with normal birth weight infants and a group of 45 mothers with low birth-weight infants, using the maternal self-report inventory(MSRV), Edinburgh Postnatal Depression Scale (EPDS) and Family APGAR(FAPGAR). Result: The total mean score was 82.57 for MSRV, 8.45 for EPDS, and 6.83 for FAPGAR with no differences between two groups. A positive correlation was found between MSRV and FAPGAR, while a negative correlations between MSRV and EPDS, and FAPGAR and EPDS. Regardless of the direction of the relationship, the degrees of the correlations were stronger in low birth-weight mothers group than in normal group. Conclusion: No differences in MSRV, EPDS and FAPGAR between the normal and the low birth- weight group considered as beneficial effects of the follow-up management which low birth-weight group was engaged in. This suggested the early intervention(follow-up) for the family with risk factor(low birth-weight) could reduce negative outcomes such as the impaired maternal self- esteem and family function, and the occurrence of postpartal depression, retrospectively.