Rubberwood (Hevea brasiliensis) has excellent physical and mechanical properties and is one of the most widely used species in Southeast Asia. However, it has poor resistance to subterranean termite attacks due to its high sugar and starch contents. The objective of this study was to evaluate the termite resistance of experimental wood-plastic composite (WPC) panels manufactured from rubberwood flour, polyethylene terephthalate, and silica in three different weight ratios (1/2/7, 1/3/6, and 1/4/5). The panels were exposed to Coptotermes curvignathus subterranean termites in a no-choice test under laboratory conditions based on Indonesian standards. Solid rubberwood used as control samples presented poor resistance, exhibiting 23.1% weight loss due to subterranean termite attack, as indicated by low termite mortality and high wood weight loss. In contrast, the WPC samples demonstrated extreme resistance, with weight loss ranging from 0.19% to 0.23%. Based on the findings of this study, the high termite mortality and overall low mass loss of the samples indicate that such manufactured panels could provide a high level of protection with regard to Indonesian standards.