Floating offshore wind turbines (FOWTs) have been developed to overcome large water depths and leverage the abundant wind resource in deep seas. However, wind-wave misalignment can occur depending on the weather conditions, and most megawatt (MW)-class turbines are horizontal-axis wind turbines subjected to yaw errors. Therefore, the power performance and dynamic response of super-large FOWTs exposed simultaneously to these external conditions must be analyzed. In this study, several scenarios combining wind-wave misalignment and yaw error were considered. The IEA 15 MW reference FOWT (v1.1.2) and OpenFAST (v3.4.1) were used to perform numerical simulations. The results show that the power performance was affected more significantly by the yaw error; therefore, the generator power reduction and variability increased significantly. However, the dynamic response was affected more significantly by the wind-wave misalignment increased; thus, the change in the platform 6-DOF and tower loads (top and base) increased significantly. These results can be facilitate improvements to the power performance and structural integrity of FOWTs during the design process.