The percutaneous coronary artery intervention(PCAI) is the most common practice to treat coronary artery disease. After PCAI，subjects may have a serious impact on quality of life (QOL) due to psychological and physical burden by self-management for their lifetime. It was reported that QOL of these patients was influenced by variable factors such as gender, age, anxiety, social support, and so on. However there were no reports to identify the difference of influencing factors by gender. Therefore this study was aimed to identify the difference of influencing factors of QOL by gender after PCAI based on Ferrans’s model. The design of the study was a cross-sectional correlational study. Data collection was conducted with a self-administered questionnaire. Subjects were 250 patients who were diagnosed with coronary artery disease and underwent PCAI at a general hospital. Hierarchical multiple regression was performed to determine the factors affecting QOL by gender. In women, anxiety, social support, perceived health status, and religion were significant variables. In men, anxiety, social support., perceived health status, diabetes, and duration after treatment were the significant variables. Regardless of gender, anxiety, social support, perceived health status and duration after PCAI was the influencing factors. Based on the results, it is recommended to provide more concern especially to women without religion and men with diabetes and underwent intervention less than 12 months. Nevertheless, anxiety, social support, and perceived health status were always considered to improve QOL of the all subjects who underwent PCAI.