Crop disease and plant illness are serious concerns that impede plant growth and reduce agricultural productivity. Utilizing nanotechnology to administer active ingredients (AIs) unveils a chance of further enhancing the effectiveness of AIs and competitiveness in the agriculture industry. In this regards, the current study assessed the release of thiabendazole from lauric acid modified hybrid nanocomposite comprised of low-cost diatoms and a copper-iron based bimetallic MOF (DE-MOF-Tbz-LA). Here, lauric acid was used to develop the pH and temperature-triggered release system, where it also serves as a gatekeeper that facilitates a prolonged release. It was found that increasing the temperature from 27℃ to 40℃ enhanced the Tbz release rate. Additionally, DE-MOF-Tbz-LA demonstrated the highest rate of release under pH 5 condition. Such, temperature and pH responsive formulations are beneficial in controlled environment agricultural systems.