Setting RAM target value for a defense system plays a crucial role in the development and design phases and the production phase as well. It is apparent that the achieved RAM target value can help maximizing the combat capability of a defense system and improving its performance throughout the system’s life cycle from acquisition phase to disposal. Usually a defense system operates according to its OMS/MP (Operational Mode Summary / Mission Profile) and it consists of several subsystems which are supposed to be operated at each utilization rate under its operating conditions and the mission profiles assigned. In this study, a method of setting RAM target value is proposed for a defense system that are composed of several independent subsystems considering their utilization rates and the mission profiles assigned. And the case study of applying the proposed method of setting RAM target value to system A is dealt with.