In recent years, social demand for wellness tourism has continued to increase due to various changes such as time and economic availability, changes in lifestyles, increase in national income, and COVID-19. In response to these social changes, this study sought to empirically derive the development tasks of wellness tourism by verifying the causal relationship between wellness tourism, self-efficacy and quality of life. In order to achieve the purpose of this study, the literature research method, interviews with Japanese local wellness tourism experts, and direct wellness tourism participants were conducted in parallel with the empirical analysis research method. The results of the study according to the empirical analysis are as follows. First, the causal relationship between wellness tourism and self-efficacy was verified to establish a significant causal relationship with only the sub-factors, social wellness and the self-efficacy hypothesis, and no significant causal relationship was established for the other factors. Second, the causal relationship tests on self-efficacy and quality of life both confirmed that a significant causal relationship was established. Third, the causal relationship between wellness tourism and quality of life was confirmed to establish a significant causal relationship between social wellness and self-esteem, and no significant relationship between the remaining subfactors.