Purpose: The purpose of this study was to determine effects of posttraumatic growth, aging anxiety, and spirituality on successful aging in late middle-aged women. Methods: Participants were 128 late middle-aged women. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficients and hierarchical multiple regression with SPSS WIN 23.0 program. Results: Results showed that significant factors influencing successful aging were spirituality and monthly income. This regression model explained 21.4% of the variance in successful aging. Conclusion: These results provided the basic data for establishing an intervention strategy to increase the level of successful aging of middle-aged women. In addition, the results suggested that development of a nursing intervention program is in need.