Aiming at the poor compression quality of traditional image compression coding (ICC) algorithm, a multi-description ICC algorithm based on depth learning is put forward in this study. In this study, first an image compression algorithm was designed based on multi-description coding theory. Image compression samples were collected, and the measurement matrix was calculated. Then, it processed the multi-description ICC sample set by using the convolutional self-coding neural system in depth learning. Compressing the wavelet coefficients after coding and synthesizing the multi-description image band sparse matrix obtained the multi-description ICC sequence. Averaging the multi-description image coding data in accordance with the effective single point’s position could finally realize the compression coding of multi-description images. According to experimental results, the designed algorithm consumes less time for image compression, and exhibits better image compression quality and better image reconstruction effect.