Purpose: This study aimed to evaluate the effects of e-health literacy, parenting stress, maternal role confidence on children’s health-promoting behaviors in mothers of infants and toddlers. Methods: The participants were 175 mothers of infants and toddlers. Data were collected from August 30 to September 24, 2022. The effects of e-health literacy, parenting stress, and maternal role confidence on children’s health-promoting behaviors in mothers of infants and toddlers were analyzed using multiple regression using IBM SPSS Statistics ver. 27.0. Results: Children’s health-promoting behaviors showed a significant positive relationship with e-health literacy and maternal role confidence, and negative relationship with children’s age and parenting stress. The factors affecting children’s health-promoting behaviors were e-health literacy, maternal role confidence, and children’s age, which explained 30.7% of the total variance in children’s health-promoting behaviors. Conclusion: This study suggests including e-health literacy and maternal role confidence for improving children’s health-promoting behaviors in mothers of infants and toddlers.