Background: The purpose of this study was to identify the factors affecting social discrimination experience on depression in the early and late elderly by region. Methods: This study used data from the National Survey of Older Koreans 2020. The subject of the study was the elderly aged 65 or older, and it was analyzed as those who responded. In order to analyze the effect of social discrimination experiences on depression, it was analyzed through binary logistic regression analysis. Results: The results of this study showed that the elderly who experienced social discrimination had a significant effect on depression. In addition, when four groups experienced social discrimination when using restaurants or coffee shops, depression was commonly affected. In addition, when both city and rural areas experience social discrimination when using sales facilities in social discrimination in the elderly, city areas are 2.21 times more likely to experience depression and 3.52 times more likely to experience depression in rural areas. The late elderly are more likely to experience 3.04 times more likely to experience social discrimination when using restaurants or coffee shops in city areas, and 3.03 times more likely to experience depression when experiencing social discrimination to make major decisions in the family in rural areas. Conclusion: In conclusion, it is necessary to prepare alternatives to prevent depression and improve mental health suitable for the characteristics of age and residential area. In addition, it suggests that personal and social efforts are needed to solve the problem of social discrimination in order to reduce depression in the elderly.