Jean Krutmann proposed that environmental factors which are part of the skin aging exposome fall into the following major categories: (i) sun radiations: ultraviolet radiation, visible light and infrared radiation, (ii) air pollution, (iii) tobacco smoke, (iv) nutrition, (v) a number of less well studied, miscellaneous factors, as well as (vi) cosmetic products. Pollution is defined as contamination of the earth’s environment with materials which interfere with human health, quality of life, or the natural functioning of the ecosystem. Whenever a prolonged and repetitive exposure to environmental stressors exceeds the skin’s normal defensive potential, there is a disturbance in the skin barrier function leading to the development of various skin diseases. Major air pollutants which affect the skin are solar ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, nitrogen oxides, particulate matter, cigarette smoke, heavy metals and arsenic. Dermal uptake depends on the deposition of air pollutants on the skin surface, the composition of epidermal lipids, and the diffusion through the epidermis to the blood vessels. An epidemiological study of elderly Caucasian women indicated that exposure to traffic related PM contributes to skin aging. A correlation was also found between NO2 and pigment spot formation in women over 50 years of age in Germany. A very recent study indicates that exposure to increased ground levels of ozone may be associated with wrinkle formation in the face. Air pollutants can modify allergenic proteins affecting their interactions with the immune system.