In order to raise the success rate of startups and to improve the industrial structure along with creating jobs in the region, it is necessary to establish the comprehensive regional startups support system. The purpose of this study is to establish and activate the system to effectively support start-up at the local level. To this end, we present recent examples of various start-up support cases that can be benchmarked at the regional level, and provide strategies and tasks on how to support start-ups at the local level. At present, the problem of startup support in Korea and Busan is the low activation of entrepreneurial ecosystem, the poor entrepreneurial environment, and the support of fragmented startups support centered on suppliers. To solve this problem, first, we refer tot the triple helix model. The triple helix model is a model in which three entities such as universities, industries, and governments interact with each other in a triple spiral, creating innovation in the region. Since making new firms in the region is becoming increasingly central to innovation strategy, this model is suitable for the integrated startups support. We provide a few cases of the integrated startups support system in the regions of the United States because of the sabbatical year. Although startups policies focus on eliminating obstacles for the startups in the US, programs and policies for start-up tend to be made and executed on a state basis. The history and current status of the Research Triangle Park(RTP) is a typical example of a triple helix model. The Arkansas Research and Technology Complex(ARTP) is a good example of entrepreneurial university through technology venture offices, GENESIS, a technology incubator, and enterprise centers. The success of Silicon Hill, a high-tech industrial cluster in Austin, Texas, is an example of a triple-helix model led by the government and universities with the industry participating in the innovation. Silicon Ally, which refers to the entire city of New York, has a special commitment of the government to startup. This study proposes five strategies(START) to support local startups. First, the initiative policy should have a systematic approach. The complex, consistent olicies are needed rather than simple, one-time policies. Second, we should try to support technology-oriented entrepreneurship rather than survivalist or lifestyle one. Third, in the startups education, it is necessary to cultivate talents by making activity-oriented curriculums. Fourth, regardless of any form of entrepreneurship, entrepreneurs must have research mind. Finally, start-ups cannot make success without cooperation so that they must form teams with various people. We propose two or three tasks in each strategy and present thirteen tasks in total.