Purpose: Because of the recent COVID-19 pandemic, there have been many cases of using portable negative pressure unit to convert general wards into temporary negative pressure isolation wards. The purpose of this study is to analyze the indoor environment of the switching type wards. Methods: Field measurements and experiments were conducted in a medical facility. Air volume, wind speed and pressure difference were measured in non-occupant state. Dispersion tests were performed with gas and particle matter. Results: The pressure difference between the wards and the corridor was higher than -2.5 Pa in normal situation. However, in the gas and particle dispersion tests, it was found that there were concerns about the spread through leakages in low-airtight walls or ceilings. In addition, it was confirmed that the pressure imbalance in ducts through the non-sealed diffusers could cause back flow during portable unit operation. Furthermore, when there was a pressure difference between adjacent wards planned to be at same pressure level, the possibility of the spread through the leakages was found. Implications: When using portable units for making switching type wards, it is necessary to create airtight space and seal the non-operation diffusers. In case of operating the air handling unit, T.A.B must be performed to adjust the duct balancing.