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18.97.9.171
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Liquid Crystal Emulsions Containing High Content Ceramides for Improved Skin Barrier Functions
( Jun Bae Lee ) , ( Minjoo Noh ) , ( Su Ji Kim ) , ( Jihui Jang )
UCI I410-ECN-0102-2023-500-001004321

In this work, we fabricated liquid crystal (LC) emulsions with fatty alcohol in order to stabilize high content ceramide in cosmetic formulation. We investigated the role of fatty alcohol and surfactant in the formation of higher order structure. As a result, we found that they play a crucial role to form higher order structure. SAXS study shows that ceramide can be incorporated up to 3% in cosmetic formulation with higher order structure and its stability was maintained up to 12 weeks at room temperature. According to WAXS study, the higher order structure can suppress the re-crystallization of ceramide in cosmetic formulation. Finally, we performed in vivo skin barrier recovery test for the damaged skin. LC emulsions with ceramide and O/W emulsions show significant effect in skin barrier recovery at D 1, D 2 and D 6 compared to the untreated condition. While only LC emulsions show significant skin recovery effect at D 14. We expect that LC emulsions are the promising skin carrier to stabilize ceramide and LC emulsions with ceramide can improve the skin barrier function..

1. Introduction
2. Materials and Methods
3. Results and Discussion
4. Conclusion
References
[자료제공 : 네이버학술정보]
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