Artery catheterization is a common procedure done in neonatal intensive care unit. However, as a complication, vasospasm, thrombosis, embolism, infection, and peripheral ischemia or skin necrosis can happen. Peripheral ischemia may further damage adjacent skin, nerve, muscle. To prevent further damage, proper management is necessary. Although there are no proper guidelines on peripheral ischemia, nitroglycerin has been commonly used as a salvage treatment, after limb elevation and warm bag application. We report a case of a preterm infant who had ischemic change after artery catheterization and improved after nitroglycerin spray, and epidermal growth factor ointment application. The patient had a successful recovery in 14 days, without any complication.