Objectives : This paper summarizes contents on fish in the Injeji and Jeoneo-Ji parts in the Imwon-Gyeongje-Ji and compares them with those in the Dong-uibogam from a Korean Medical perspective. Methods : Most of the knowledge of fish in the Imwon-Gyeongje-Ji is based on preceding material medica studies such as the Dongui-bogam in Joseon, the Bencao-gangmu in China, and the Hwahan Samjaedohoe in Japan. The influential relationships and the process of change among these knowledge information were examined within the context of each literature's development or through identifiable changes in knowledge on each particular kind of fish. Results & Conclusions : In the Imwon-Gyeongje-Ji, the consisting 16 parts are organically connected, sometimes functioning as cross-references. In particular, the medical contents on the efficacy of fish for treating disease is closely linked to contents on fish ecology and environment as written in the Jeoneo-Ji, which deals with the field of living things. On the more detailed knowledge on about 30 kinds of fish, one could grasp the formation process and changes of East Asian traditional knowledge on fishkind among historical study of influential Chinese texts, new stimulation and methodology through Japanese literature on natural history, and dynamic processes of inheriting and selectively accepting traditional knowledge of Joseon.