This study investigated the effect of fly ash content on the isothermal hydration heat of cement pastes. Two different pastes with fly ash content were studied to cure at 35°C. The hydration heat flow deceleration stage of slurry was simulated and compared by Jander Equation and Ginstling-Brounshtein Equation. The results show that Jander Equation and Ginstling-Brounshtein Equation have certain defects in the modeling of the deceleration stage of the heat flow of cement fly ash paste, and the fitted curve can not describe the deceleration stage well.