Objectives: This study aimed to evaluate the effect of detergents containing a centella quantitative extract and dipotassium glycyrrhizinate and potassium nitrate on patient hygiene performance index, gingivitis index, gingival bleeding index, EPT, and halitosis. Methods: A parallel comparison, randomized, double-blind, controlled trial was conducted for 8 weeks with 60 adult men and women as participants. Results: According to the PMA index, gingival index of Talbott, gingival hemorrhage index, Turesky’s plaque index, and bad breath measurement, there was a statistically significant difference between the experimental group and the control group after 4 weeks (P<0.05). Conclusions: It was confirmed that the bad breath reduction effect, gingival bleeding improvement effect, gingivitis inflammation effect, removal of the gingival microbial membrane, and syringin can be expected to relieve symptoms.