Objectives : This study analyzes the theoretical and clinical reasoning process of Zhao Xian-Ke that argued that the Mingmen is the true monarch of the body. Methods :The analysis focuses on how the arguments of Li Dong-yuan and Zhu Danxi was succeeded and supplemented by Zhao Xian-Ke into a new theoretical system in the Yiguan(醫貫). Results & Conclusions : Zhao’s argument that the Mingmen is the true monarch of the body is a result of emphasis on the meaning of innate Qi that is separate from the Water and Fire of the Heart and Kidney, which is derived from the innate Qi concept of Li Dong-yuan’s Spleen-Stomach Theory. Zhu Danxi’s Ministerial Fire Theory was also accepted through the innate Qi concept of Ministerial Fire and True Yin, which contributed to the establishment of a systematical theory on Mingmen, Miniterial Fire, and True Yin as constituents of innate Qi. In conclusion, the Neijing’s explanation that the Heart radiates Shenming as the monarch organ has been modified into innate Qi from the Mingmen reaching the Heart to radiate Shenming.