The hypoglossal nerve, the twelfth cranial nerve, is the pure motor nerve fibers which supplies general somatic efferent innervation of hyoglossus, genioglossus and styloglossus muscles and all intrinsic muscles of tongue.(1) The hypoglossal nerve palsy (HNP) makes patients uncomfortable in controlling speech and swallowing, the HNP has been reported in many conditions like tumors, head trauma, stroke, hysteria, multiple sclerosis.(2) Isolated unilateral HNP after general anesthesia is a rare complication. In this paper, we report a case of isolated unilateral HNP which occurred after reconstruction of blow out fracture and recovered completely with conservative therapies.