Recently, the demand for high fluidity concrete has been increased due to skyscrapers. However, it has its own limits. First of all, high fluidity concrete has large variation and through trial & error it costs lots of money and time. Neural network model has repetitive learning process which can solve the problem while training the data. Therefore, the purpose of this study is to predict optimum mix design of 40MPa, 60MPa high fluidity concrete by using neural network model and verifying compressive strength by applying real data. As a result, comparing collective data and predicted compressive strength data using MATLAB, 40MPa mix design error rate was 1.2%~1.6% and 60MPa mix design error rate was 2%~3%. Overall 40MPa mix design error rate was less than 60MPa mix design error rate.