The fact that the skin and scalp are always exposed to external environment makes them easily susceptible to inflammatory problem caused by various chemicals or physical stimuli. In this context, the current study examined how Boswellia affects the hair cycle of inflammatory skin or scalp caused by DNCB (2,4-dinitrochlorobenzene) in mice. For the study, 5 week-old male Balb/c mice were selected and DNCB was used to cause contact dermatitis in the mice’s skin at the back. Next, Boswellia was administered and all visual changes in the skin were followed. Furthermore, histological analysis and transcription through hematoxylin & eosin dyeing method were done to understand Boswell's mechanism of action toward atopic dermatitis. The symptoms of dermatitis visually appeared to be significantly improved on Boswellia administration. Histological analysis showed the keratin layer in the DNCB-B group and the shape of a hair follicle as round. Analysis of transcriptionome revealed an increase in gene Gprc5d, Msx2, Ptch2, Wnt10b, Dsg4, Kratap4-16, Hc16, Apcdox and S21 mR in the DNCB-B group compared to the positive control DNCB group. In conclusion, Boswellia administration was found to help improve the symptoms of DNCB dermatitis, and the changes in hair-related gene expression might improve the hair cycle or growth impediments caused by dermatitis.