연구배경: Serous adenocarcinoma of the uterine cervix is an extremely rare variant of cervical adenocarcinoma. The aim of this study was to evaluate the clinicopathological and molecular features, and outcomes of serous adenocarcinoma of the uterine cervix (SACC). 대상 및 방법: This was a retrospective study that the clinical and pathological data of seven patients diagnosed with SACC after hysterectomy evaluated at the gynecologic oncologic centers between 2010 and 2019. Five cases were diagnosed at stage IB, and two at stage IV. All patients underwent radical hysterectomy with bilateral salpingo-oophorectomy and subsequently received postoperative radiotherapy or chemotherapy. Immunohistochemical study was practiced for evaluation of p53 expression. 결과: One patient showed persistent disease and two patients suffered recurrence. Immunohistochemical study showed that 3 (43%) of the 7 patients were positive for p53, and among these 3 patients, two with diffuse strong p53 expression experienced an aggressive course with recurrences at pelvic lymph nodes, lung, and brain. 결론: High p53 expression and advanced stage may be associated with poorer clinical outcomes in SACC, and suggest immunohistochemistry may contribute to the prediction of prognosis.