Background: Surgical interventions are part of the therapeutic arsenal, especially in refractory vitiligo, but comparison of treatment outcomes between the different surgical procedures has not been studied. Objectives: To investigate the treatment response of different surgical modalities in vitiligo. Methods: We comprehensively searched the MEDLINE, Embase, Web of Science, and Cochrane Library databases from the times of their inception to April 18, 2020, using the keywords “vitiligo,” “surgery,” “autologous,” "transplantation," "suction blister" and “graft”. Random effects meta-analyses using the generic inverse variance weighting were performed. The primary outcomes were the at least 90% repigmentation rates, calculated by dividing the number of participants who showed the corresponding repigmentation by the total number of participants. Results: A total of 118 studies related to punch grafting, suction blister grafting, thin skin grafting, epidermal cell suspension, follicular sheath cell suspension, and cultured epidermal cell suspension were identified. Overall, >90% repigmentation rate of surgical interventions was 52.69% (95% CI, 46.87-58.50). Thin skin grafting showed the highest repigmentation rate. The treatment response was related to the age, vitiligo subtype, and anatomic site. Conclusion: Surgical intervention can be an effective option for refractory stable vitiligo. The appropriate procedure should be recommended regarding the age, site, size of the lesion, and costs.