Background: Recent developments in material technology have revealed boehmite as a new therapeutic modality for use in wound healing and scar reduction, indicating its beneficial effects. However, the biological bases of the beneficial effects of boehmite remain unknown, and the use of boehmite to promote hair growth has not yet been studied. Objectives: This study was aimed to investigate the effect of boehmite on hair growth and the underlying mechanism. Methods: Minoxidil 3%, boehmite 1%, 3%, 5% and control vehicle cream were topically applied to the shaved dorsal skin of C3H/HeJ mice 5 days per week for 7 weeks. For in vitro model, we observed dose-dependent proliferation of human dermal papilla cell (hDPC). Reverse transcriptionquantitative polymerase chain reaction (qPCR) and western blot was carried out for expression analysis of hair growth related genes. Results: The length and size of hair follicle significantly increased in boehmite-treated mice. Boehmite increased hDPC viability, alkaline phosphatase (ALP) activity, AKT/GSK3/β-catenin pathway activity, anagen-related gene expression and VEGF secretion. In addition, it accelerated hair regrowth in a catagen-anagen transition model via upregulation of β-catenin signaling and follicular cell proliferation. Conclusion: Our results indicate that bohemite accelerates hair growth, partly via its effects on critical events in the active phase of the hair follicle cycle.