In the preliminary design stage of prestressed concrete (PSC) box girder bridges, the design factors decided by inexperience designer could heavily affect to the results of final design. There is a possibility that the design ends up with an excessively wasteful design. To achieve an economical design with preventing an excessive design, the optimal design technique has been developed using ADS optimal program and SPCFRAME in this study. The objective function for the optimal design problem is the material cost of box girders and constrained functions are constituted with design specifications and workability. The Sequential Unconstraint Minimization Technique (SUMT) is used for the optimal design in this study. We designed an uniform cross-section bridge and an ununiform cross-section bridge in the same design condition by optimal design technique developed in this study. Analyzing the results obtained for various tendon layouts, we suggest a standard tendon layout which gives the most effective structural behavior.