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Liver stiffness measurement and outcomes of living donor liver transplantation
( Sang Jin Kim ) , ( Jong Man Kim ) , ( Jinsoo Rhu ) , ( Gyu-seong Choi ) , ( Jae Berm Park ) , ( Jae-won Joh )
UCI I410-ECN-0102-2021-500-001255271
이 자료는 4페이지 이하의 자료입니다.
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Background: Liver stiffness measurement (LSM) is a non-invasive method for evaluating liver fibrosis. The aim of this study was to evaluate the correlation between LSM and outcomes of living donor liver transplantation. Methods: From January 1, 2014 to May 30, 2019, patients who received living donor liver transplantation were evaluated by Fibroscan. Baseline characteristics, preoperative donor LSM, and recipient 1-month and 1-year postoperative LSM were evaluated. Graft survival, patient survival, HCC recurrence, and rejection were analyzed with LSM values. Results: Total 237 patients who received living donor liver transplantation were included, retrospectively. One hundred and seventy-four patients were infected with hepatitis B virus. Donor LSM was evaluated in 233 patients, 1-month LSM in 206 patients, and 1-year LSM in 62 patients. Either donor LSM, recipient 1-month, or 1-year LSM did not significantly affect graft survival and HCC recurrence. High donor LSM was associated with patient death, especially when donor LSM was more than 5 kPa (hazard ratio [HR], 3.58; P=0.004). Regarding T-cell mediated rejection (TCMR), high 1-year LSM was associated with high risk, especially when the 1-year LSM was more than 8 kPa (HR, 5.42; P=0.008; multivariate). One-year LSM (>8 kPa) was also associated with TCMR occurring after 1 year (HR, 7.01; P=0.047; multivariate). In hepatitis B virus patients, LSM had a greater influence on patient death and TCMR. Conclusions: Preoperative donor LSM more than 5 kPa was significantly associated with patient death. Recipient 1-year LSM more than 8 kPa was associated with both TCMR over the entire period and TCMR 1-year after transplantation. This tendency was slightly more pronounced when patients were infected with hepatitis B virus.

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