Purpose: This study examines the factors affecting patient-centered nursing among regional public hospital nurses, with a focus on communications, professionalism, organizational culture, and teamwork. Methods: We included 162 nurses working at five regional public hospitals in G province. Data were collected from October 7 through October 19, 2019 using self-report questionnaires. Data were analyzed using descriptive statistics, t-test or ANOVA, Pearson’s correlation coefficient, and hierarchical multiple regression analysis using SPSS (Version 24.0). Results: The factors affecting patient-centered nursing included an innovation-oriented culture, working in an intensive care unit, hierarchy-oriented culture, and nursing professionalism. These variables explained 43% of patient-centered nursing. Conclusions: These results suggest that enhancing an innovation-oriented culture is necessary for patient-centered nursing and to improve nurses’ awareness about the importance of patient-centered nursing. Moreover, organizational efforts are required to increase nurses’ professionalism through suitable educational programs in regional public hospitals.