Purpose : The purpose of this study is to investigate nursing students’ levels of and relationships between college-related stress, self-efficacy, social support, and interpersonal skills. Methods : This study involved 352 nursing students at K University in B City, each who understood the study’s purpose and agreed to participate in the study. The study’s data were collected between April 8 and 19, 2019 and were analyzed using the SPSS for Windows 22.0 program based on frequencies, percentages, means, and standard deviations as well as a t-test, analysis of variance, post-hoc test, and correlation analysis results. The Scheffe test was performed for the post-hoc test, and the Pearson correlation coefficient was employed for the correlation analysis. Results : College-related stress showed statistically significant negative correlations with self-efficacy (r=-.310, p<.001), social support (r=-.312, p<.001), and interpersonal skills (r=-.226, p<.001). However, self-efficacy exhibited statistically significant positive correlations with social support (r=.548, p<.001) and interpersonal skills (r=.524, p<.001), and social support showed a statistically significant positive correlation with interpersonal skills (r=.644, p<.001). Therefore, higher levels of self-efficacy and social support and a lower level of college-related stress result in corresponding higher levels of interpersonal skills. Conclusion : Based on the results of this study, it is necessary to find measures to lower nursing students’ college-related stress and increase their self-efficacy and social support, as well as to develop and operate specific intervention programs that can help enhance their interpersonal skills.