Methane is recognized to contribute to the major portion of global warming. The stable C-H bond in methane requires the large amount of noble metal in catalyst to be oxidized completely at low temperature. Thus, we aims at lowering the light-off temperature by introducing the catalyst-plasma hybrid reaction system. The complete oxidation of methane was carried out in a dielectric barrier discharge glass tube reactor. The palladium-based catalysts were used as oxidation catalyst. In the presence of both plasma and catalyst, methane was oxidized to produce mostly CO₂ with low CO selectivity at room temperature, indicating that the complete oxidation was successfully performed with the aid of catalyst. The role of plasma was to oxidize methane to produce CO, which was subsequently oxidized to CO₂ over catalyst at low temperature. Interestingly, it was found that the synergistic effect of plasma-catalysis hybrid system on methane oxidation existed substantially only under specific condition.