Purpose : The purpose of this study was to investigate the Health-related Indicators according to the restricted activity and health-related quality of life of osteoarthritis patients based on Korean National Health and Nutrition Survey. Methods : The data collected for this study used the IBM SPSS WIN21.0 statistical program. Analyzed for descriptive statistics, simple frequency and proportion, Chi-squared test. Results : Restricted Activity was statistically significantly related to self-assessed health, stress, depression, suicidal ideation, and smoking. Health-related quality of life was statistically significantly related to self-assessed health, BMI, stress, depression, suicidal ideation, and walking practice. Conclusion : The findings of this study suggest that osteoarthritis patients need measures to minimize restricted activity and improve health-related quality of life.