Purpose: The purpose of this study was to develop and examine the effects of a simulation learning module based on schizophrenic patients care on the knowledge of schizophrenic patients care, learning self-efficacy, and nursing skill performance of nursing students. Methods: Junior nursing students with no mental health nursing experience from two different colleges in G city participated. A total of 64 participants were classified into the experimental group (31) and the control group (33). This study was conducted based on the Jeffries simulation model, and the simulation learning module based on schizophrenic patient care was developed based on the Instructional System Design simulation learning module based on schizophrenic patients care comprising the module I lecture, the module II case-based team learning, and the module III standardized patient-based simulation learning. Results: There were significant increases in the knowledge of schizophrenic patients care (t=2.85, p=.006), learning self-efficacy (t=3.42, p=.001) and nursing skill performance (t=16.69, p<.001) in the experimental group compared to the control group Conclusion: The simulation learning module based on schizophrenic patients care can be useful in the educational and clinical environment as effective strategies in contributing to nursing education and clinical changes.