This study seeks to test the impact of states’ worker supplement programs on the unemployment of low-income females. Worker supplement programs were implemented to cover more needy people and to meet tougher work requirements in response to the enactment of Deficit Reduction Act (DRA) of 2005. Methods. We utilize a difference-in differences method using panel data for fifty states over a 9-year period (2005-2013). Results. Our empirical analysis shows that states implementing worker supplement programs achieve lower unemployment among low-income females compared to states that did not implement the programs. We also find that higher refund rates of state Earned Income Tax Credit and monthly benefits of Unemployment Insurance program are effective in reducing unemployment of low-income females. Conclusion. States can effectively reduce the unemployment of low-income females by reallocating TANF and/or MOE funds and investing in worker supplement programs.