Objectives : The purpose of this case study is to report the effect of Korean medicine on hand-foot syndrome(HFS) casued by sorafenib(nexavar) in hepatocellular carcinoma. Methods : The patient, 77-year-old patient complaining with pain, swelling and erythema on both hands and feet which is characterized as HFS was treated with Jaungo. We evaluated the symptoms by Numeric Rating Scale and pictures. Results : The symptoms of HFS has been alleviated during the treatment. Conclusions : We suggest Jaungo as one of the alternative therapies for HFS due to sorafenib.