Purpose: The companies must be located in the area, scale up, create jobs, and return to the local economy. This paper attempted to analyze empirically the relationship between regional context and entrepreneurial orientation(EO) in the region of Korea. Methods: This paper analyzed survey data and regional statistics. We measured EO by region and then examined which regional context affect EO. Regional contexts were measured by population, economic size, budget size, firm size, innovation capacity, and education level. EO was measured by innovativeness, risk taking, proactiveness, autonomy, competitive aggressiveness, and need for achievement. Results: EO was high in the region where the budget size per thousand population, the number of manufacturers per thousand population, the number of new corporations per thousand population, the number of R&D personnel per thousand population, and the number of students of higher education institutions per thousand population were high. Conclusion: The implications of this paper are that regional context affect EO, and there are differences in budget scale, firm size, innovation capacity, and education level. In regions with many investment resources for innovation and startups and manufacturers, the number of R&D personnel and students of higher education institutions (future R&D personnel), in particular, determines EO.