Background: Interstitial lung diseases(ILD) are heterogeneous group of lung diseases that require a multidisciplinary approach through discussion with clinicians, radiologists, and pathologists. Surgical lung biopsy is the gold standard for pathologic diagnosis of ILD. Recently, the usefulness of transbronchial cryobiopsy (TBC) has increased in the assessment of ILD. As far as we know, there is no study in Korea on the role of TBC in ILD diagnosis, yet. This study first evaluated the significance of TBC in suspected cases of ILD in Korea. Methods: The medical records of 17 patients suspected of ILD who were performed TBC at Ulsan University Hospital from August 2016 to June 2019 were retrospectively evaluated. Results: Seventeen patients with a mean age of 67 years were included in this analysis and there were 47%(eight patients) of women. The 1.9 mm sized probe was used for three patients and 2.4 mm sized probe was used for 14 patients. The median number of specimens per procedure was four (range; 1-9). The mean diameter of the specimens was 0.5 cm(range; 0.2-1.2cm). The diagnostic yield of TBC was 47.1%(eight patients). The frequent histopathologic results included usual interstitial pneumonia(two patients), organizing pneumonia(two patients) and adenocarcinoma(two patients). In the multidisciplinary diagnosis, they were diagnosed with idiopathic pulmonary fibrosis(two patients), cryptogenic organizing pneumonia(two patients) and adenocarcinoma(two patients). Four of the nine patients with non-diagnostic histopathologic patterns were able to be diagnosed after a multidisciplinary review. As a result, the number of patients who could be diagnosed by TBC increased to 12 patients(70.6%). The complication occurred in eight patients including mild bleeding (three patients) and pneumothorax(four patients). Conclusions: The diagnostic yield of TBC in this study was 47.1% and increased to 70.6% after a multidisciplinary diagnosis. The value of TBC as the alternative methods of surgical lung biopsy should be evaluated through further study.