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Role of Gut Microbiota in Type 2 Diabetes Mellitus and Its Complications: Novel Insights and Potential Intervention Strategies
( Birhanu Woldeamlak Ketsela Yirdaw ) , ( Belete Biadgo )
UCI I410-ECN-0102-2021-500-000618127

Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide. The disease is believed to involve a complex process involving genetic susceptibility and environmental factors. The human intestine harbors hundreds of trillions of bacteria, as well as bacteriophage particles, viruses, fungi, and archaea, which constitute a complex and dynamic ecosystem referred to as the gut microbiota. Increasing evidence has indicated changes in the gut microbiota composition or function in type 2 diabetic patients. An analysis of ‘dysbiosis’ enables the detection of alterations in the specific bacteria, clusters of bacteria, or bacterial functions associated with the occurrence of type 2 diabetes. These bacteria are involved predominantly in the control of inflammation and energy homeostasis. This review attempts to show that the gut microbiota are important factors for the occurrence of type 2 diabetes and are important for the treatment of gut microbiota dysbiosis through bariatric surgery, fecal microbiota transplantation, prebiotics, and probiotics. (Korean J Gastroenterol 2019;74:314-320)

INTRODUCTION
GUT MICROBIOTA ROLE IN DM PATHOGENESIS
PATHOPHYSIOLOGY OF THE GUT MICROBIOTA ON DIABETICS
COMPLICATIONS OF THE GUT MICROBIOTA DYSBIOSIS ON T2DM
GUT MICROBIOTA AS THERAPEUTIC ALTERNATIVES FOR DM
CONCLUSIONS AND RECOMMENDATIONS
REFERENCES
[자료제공 : 네이버학술정보]
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