The purpose of this study was designed to estimate activation of a Malondialdehyde(MDA) and total antioxidant status(TAS) in human by administration the ginseng for eight weeks. For this purpose, K college students(n=7) was to be tested to a treadmill runing from rest until their entire physical exhaustion. Subject`blood was collected before, immediately after, 10 and 30 minutes after the exercise to be examined. The results of this study can be summarized as follows; 1. Malondialdehyde(MDA) were significantly lower than before. 2. Total antioxidant status(TAS) were significantly higher than before, Particularly TAS(total antioxidant status) were higher than before that in all-out time. In conclusion, the ginseng was decreased that oxydative stress in all-out time. Therefore, Ginseng was effected by Antioxidants.