Pancytopenia is reductions in all the three major cellular components of blood, and it is the simultaneous presence of anemia, leukopenia, and thrombocytopenia. It complicating pregnancy is rare. But during pregnancy it could be life-threatening for both mother and child. Pancytopenia, which occurs early in pregnancy, is particularly challenging in clinical settings because pregnancy management and outcomes are entirely dependent on underlying causes. The assessment of patients with pancytopenia requires a comprehensive approach and it can be difficult to determine the root cause when considering various causes, including drugs, autoimmune conditions, malignancies, infections, hemophagia, and inheritable conditions. While bone marrow failure syndromes and malignancies are important causes, certain non-malignant conditions such as infection and nutritional anemia are equally important causes. We present a 29-year primigravida woman with an uneventful medical history who was referred at 17weeks gestational age as a case of fever with pancytopenia. She had a cough and sore throat. And serum C-reactive protein and procalcitonin levels were elevated. She was admitted, investigated and diagnosed as a case of pancytopenia with peripheral blood smear showing normocytic normochromic anemia with aniso-poikilocytosis, leukopenia with lymphopenia (10%190/uL), and moderate thrombocytopenia. She was treated intravenous antibiotics and after the infection has been cured, the pancytopenia has improved spontaneously after 3 weeks later. We report a case who developed pancytopenia following upper respiratory infection in the rare case.